mice, in several studies. Buspirone is an anxiolytic psychoactive drug of the azapirone chemical\nclass that is not related to benzodiazepines, unlike most drugs predominately used. The purpose\nof the present study was to examine interaction between magnesium (Mg) and buspirone as a partial\nagonist of 5-HT1A receptors in producing anxiolytic-like activity in the elevated plus maze. The\nanxiolytic-like effect of Mg (50, 100 and 200 mg/kg, orally), buspirone (5 mg/kg, i.p) and its interaction\nwith Mg (50 mg/kg) was evaluated after ten days treatment. Mg given at all doses (50, 100\nand 200 mg/kg) and buspirone (5 mg/kg) induced an anxiolytic-like effect significantly increasing\nthe percentage of the time spent in the open arms (%OAT), the percentage of the open arm entries\n(%OAE) and number of total entries. Percent time spend in open arms was reduced when buspirone\ncoadministered with Mg (50 mg/kg) compared to Mg alone. However, the number of entries\ndid not change significantly. No synergistic interaction (increased time in open arms and number\nof open arm entries) between Mg and buspirone was observed, in this test, on the contrary, %OAT\npreserved about buspirone effects and %OAE remained around Mg effect. The obtained data indicate\nthat Mg may act partly via serotonergic receptors due to buspirone�s inhibitory action as a\npartial agonist of serotonin receptor.
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